4th ENOVA ADJUVANT WORKSHOP, 20-22 September 2021, Genova, ITALY
This workshop was planned for 23-25 March 2020, but due to COVID-19 pandemic have been moved to a hybrid (online-physical) at the same place but new time point: 20-22 september 2021.
The next ENOVA workshop will held in Genova, ITALY. Beside the administrative meetings, such as MC meeting or networking activity, there will be one keynote presentation (Vaccine-controlled infective diseases and cancer burden: achievements and perspectives, Prof. Alberto Izzotti, Genova University) and five scientific sessions (Improving existing adjuvant-based formulations; Novel vaccine adjuvants; Scale-up procedures for adjuvant production; Assays for the characterization of antigen-adjuvant formulations, and Selecting protocols for preclinical testing and down selection).
The procedure for registration of the meeting is:
- before August 28th you sign up for participation via the doodle link: https://doodle.com/poll/kxkkcqb2su9mkdmf. There is an upper limit of 60 participants, so do not hesitate.
- Hereafter you will receive an official COST invite, where you register your participation.
- At the same time (deadline August 28th), you submit a title for a lightning talk (10-15 minutes), where you suggest a focus are among the five listed above. Also write 3-4 lines about the topic of your talk. Send to me (firstname.lastname@example.org). There will be a maximum of 30 talks (prioritized by submission sequence)
- Early September, you will receive a first draft of the detailed program.
Agenda Monday September 20th 2021
13:30 – 13:40 Welcome to Genova, Camillo Rosano (IRCCS Policlinico San Martino - Genova, Italy) & Giacomo Drago (CEO of GIAMpharma Int).
13:40 – 13:45 Introduction to ENOVA & the 4th Adjuvant Workshop, Dennis Christensen (SSI, DK)
13:45 – 14:15 Keynote: Vaccine-controlled infective diseases and cancer burden: achievements and perspectives Proff. Alberto Izzotti, (Genova University, Italy)
14:15 – 15:30 Session 1: Improving existing adjuvant-based formulations
- To evaluate whether mucosal adjuvants enhance the immunological responses of pigs immunized with Nipah Virus F and G protein replication incompetent paramyxovirus vectored vaccines, Louise Cosby (Agri-Food and Biosciences Institute, Belfast, UK) online
- Using microcontainers for oral delivery of vaccines, Philip Hassing Ronøe Carlsen (PhD student DTU, Denmark) Genova
- The adjuvant LT-K63 enhances B cell activation and survival factors expression in neonatal mice - comparative study of LT-K63 and other adjuvants on the induction of germinal center and ASC, Stefania P. Bjarnarson (University of Iceland/National University Hospital of Iceland) online
15:30 – 16:00 Coffee break
16:00 – 17:30 Session 2: Novel vaccine adjuvants
- Development of new adjuvants / adjuvant formulations based on purified Astragalus saponin, Astragaloside VII (AST VII), Nilgün Yakuboğullari (İzmir Institute of Technology, Turkey) online
- Protein corona and rigidity affect regulatory T-cells induction using liposomes, Bram Slütter (LUMC, NL), online
- Thermogelling and mucoadhesive hydrogels as sublingual boosters for obtaining mucosal immunity"., Lorena Garcia del Rio, (STSM, PhD student, University Santiago de Compostella, Spain) Genova
- In vitro investigations of adjuvant properties of selected novel PRR agonists, Samo Guzelj (University of Ljubljana, Slovenia) online
- The IC-tagging multipurpose platform, Tomas Boirazian (NIBSC, UK) online/Genova
Evening on your own
Agenda Tuesday September 21st 2021
08:30 – 10:00 Session 3: Assays for the characterization of antigen-adjuvant formulations
- Comparison of different assay formats for characterisation of adjuvant activity, Sandra Diebold (NIBSC, UK) online
- Ex-vivo assessment by Comet assay of Allostatine, Imène Ben Toumia (Faculty of Pharmacy of Monastir, Tunesia) Genova
- Investigating the role of antigen-adjuvant interaction, Katharina Wørzner (PhD Student, SSI, Denmark) Genova
- Optimisation of a vaccine against Melioidosis, Siobhán McClean (University College Dublin, Ireland) online
10:00 – 10:30 Coffee break
10:30 – 13:00 MC meeting (only for members of the Management Committee)
13:00 – 14:00 Lunch
14:00 – 15:30 Session 4: Selecting protocols for preclinical testing and down selection
- Vaccine Adjuvants Differentially Affect Kinetics of Antibody and Germinal Center Responses, thus Confounding Adjuvant Comparisons, Dennis Christensen (SSI, Denmark) Genova
- Chitin derived polymers as vaccine adjuvants, Ed Lavelle.(Trinity College Dublin, Ireland) Genova
15:30 – 16:00 Coffee break (group photo)
16:00 – 17:00 Session 5: Scale-up procedures for adjuvant production
- Preparation of liposomal vaccine adjuvants with hydrodynamic flow-focusing microfluidics, Tandrup Schmidt, (SSI, Denmark) online
- Modelling a pandemic INFLUENZA vaccine manufacturing using CrisBio® technology, Ana Falcon (Algenex, Spain) online
20:00 Gala Dinner at the Ristorante "I tre merli"
- https://www.itremerli.it/ https://email@example.com,8.927112,18.75
09:00 – 09:30 Summary of MC meeting discussion
9:30 – 10:00 Dennis Christensen – funding opportunities for further network activities- participants who will join online/Genova are encouraged to interact in this session and give suggestions about funding opportunities.
10:10 – 12:00 Network discussions
- Introduction of COST virtual networking tools (Brankica Filipic)
- Activities of Grant Period 5 (6 month extension period)
- Planning of 5th Adjuvant Workshop (Israel) (Uri Marchaim and Jacob Pitcovski)
- Outline of joint ENOVA manuscript(s)- (Maria Lawrenz)
- Preparation of ENOVA Final Assessment Report (Maria Lawrenz)
- Continuation of ENOVA network (Maria Lawrenz and Dennis Christensen)
12:00 End of meeting